Impact of COVID-19 infection on left ventricular systolic and diastolic functions.

Hazem Galal Mohamed, Cardiovascular Department, Faculty of Medicine, Mansoura University, Egypt.Follow
Maged Zaghloul Mohamed Amer, Cardiovascular Department, Faculty of Medicine, Mansoura University, Egypt
Aml Fathy Moustafa, Pulmonology Medicine Department, Faculty of Medicine, Mansoura University, Egypt
Shady Hussein Mohamed, Cardiovascular Department, Faculty of Medicine, Mansoura University, Egypt.

Corresponding Author

Dr. Hazem G. Mohamed (Hazem G. Mohamed El-Morshedy)

Subject Area

Cardiology

Article Type

Original Study

Abstract

Background: SARS-CoV-2, the pathogen behind COVID-19, often involves the cardiovascular system due to high ACE2 receptor density in myocardial tissue. While immediate cardiac complications are recognized, the persistent effects on left ventricular (LV) performance require further investigation through echocardiography.

Aim: This study aimed to comprehensively describe the sequelae of COVID-19 infection on the left ventricle using echocardiography

Methods: The study included 100 participants. Cardiac function was assessed using a standard 12-lead ECG and transthoracic echocardiography. LV systolic function was evaluated using the Biplane Simpson Method, and myocardial contractility was further analyzed using Speckle-Tracking Echocardiography (STE).

Results: The mean age was significantly higher in the COVID-19 group (34.24 ± 8.71 vs 30.48 ± 5.85 years; P=0.013). No significant differences were found in LVEF or longitudinal strain between COVID-19 survivors and controls. This aligns with several previous studies reporting preserved LV function in non-critical survivors.

Discussion & Conclusion: These data demonstrate clinical stability in LV performance during the post-acute phase, suggesting that global systolic function is largely unaffected in this cohort. However, the use of sensitive indicators like Global Longitudinal Strain (GLS) is recommended for patients with persistent symptoms like dyspnea. Limitations include the small sample size, and prospective studies with longer follow-up periods are recommended.

Recommended Citation

Mohamed, Hazem Galal; Amer, Maged Zaghloul Mohamed; Moustafa, Aml Fathy; and Mohamed, Shady Hussein (2026) "Impact of COVID-19 infection on left ventricular systolic and diastolic functions.," Mansoura Medical Journal: Vol. 55 : Iss. 6 , Article 8.
Available at: https://doi.org/10.58775/2735-3990.1572