Subject Area
Dermatology
Article Type
Original Study
Abstract
Background: The precise etiology of vitiligo remains unclear; nonetheless, it is predominantly regarded as an autoimmune disorder. This work aimed to compare serum levels of IL-19 and IL-38 between patients with non-segmental vitiligo (NSV) and healthy controls (HC). Patients and Methods: This study included 88 participants, evenly split into two groups: 44 individuals with non-segmental vitiligo and 44 healthy controls. Both groups underwent full history taking. The Vitiligo Area Severity Index (VASI) score and Vitiligo Disease Activity (VIDA) score were used to assess disease severity and activity. The levels of human IL-19 and IL-38 were also measured.
Results:Serum IL-38 and IL-19 levels were significantly higher in the vitiligo patients compared to the controls (p
Conclusion: We conclude that both IL-19 and IL-38 may be mediators in the development of vitiligo. These findings underscore the significance of cytokine profiling in vitiligo for both diagnosis and the assessment of disease progression and therapy efficacy.
Recommended Citation
Al Maaddawy, Reem Ahmed; Selim, Mohamed Kh.; Ismail, Ahmed Fawzi; Hasan, Ahmad S.; and Hassan, Manar Ali
(2026)
"Comparative Study between Serum Levels of Interleukin-19 and Interleukin-38 in The Egyptian patients with Non-Segmental Vitiligo,"
Mansoura Medical Journal: Vol. 56
:
Iss.
1
, Article 16.
Available at:
https://doi.org/10.58775/2735-3990.1554
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
