Article Type
Original Study
Abstract
Adriamycin (ADR) is an anthracy-clic antibiotic (Di Marco et af., 1969). It is considered now to be a very effective and useful chemotherapeutic agent in the treatment of many human solid tumors and malignant heamato-logical processes {Carter et al., 1972). However, its extensive use al doses adequate for effective antitumor therapy is restricted by the appearance of a severe cardiotoxicity (Adamson, 1974; Bristow et al., 1978; and Nagineni, 1985). Little is known about the effect of ADR on the kidney function and its relation to any pathological changes. Our study aims to reveal this relation after 4 and 8 weeks of ADR treatment. Materials and methods Animals: Experiments were carried out on white male rats weighing be- tween 200-300 grams. They were allowed acess to food and water ad. libitum. Five rats were injected i.v. with normal saline twice/week (served as control), and twinty rats arranged in two groups underwent treatment with adriamycin (1 mg/kg b.w. twice/week i.v.) for four weeks and eight weeks respectively. Urine samples were collected over 24 hours period from control and adriamycin treated groups by using metabolic cages. Then the animals were sacrified for sampling analysis. Biochemical and hlstochemical investigations: Serum and urinary creatinine were determined by the method of Whiting et al., 1982. Creatinine clearance was calculated applying the following formula : Clearance = (P x V / u) m/min.
Recommended Citation
El.Gindy, M; Gamil, T; and Sirag, S
(1990)
"STUDIES ON ADRIAMYCIN SIDE EFFECTS ON THE RENAL FUNCTION AND MORPHOLOGY IN RATS,"
Mansoura Medical Journal: Vol. 19
:
Iss.
1
, Article 11.
Available at:
https://doi.org/10.21608/mjmu.1990.138838
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