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Article Type

Original Study

Abstract

B-adrenergic blocking agents have received major attention because of their utility in the management of car­diovascular disorders (Prichard et al., 1980). Furthermore, it was reported that some patients suffering from rheumatoid arthritis or other connec­tive tissue disorders had improved fol­lowing propranolol therapy for co­existent hypertension or angina pec-tons {Moore etal., 1978). Reir (1971) reported that, the hu­man peripheral lymphocytes have ad-renergic sensitivity corresponding to alpha and beta receptors; alpha-adrenergic stimulation associated with augmentation, and beta with inhibition of lymphocyte transformation. Also lymphoid tissue is known to possess a high content of norepinephrine pre­sumably related to its sympathetic (Madden, 1971). Furthermore, B-adrenoceptor blockers, may have im-munomodulatory properties. Such a possibility was suggested by animal studies showing that propranolol can inhibit mitogenic activation of lym­phocytes (hnderson eta 1., 1981), and can enhance antibody production in mice (Nakazawa et al., 1976). The present study was conducted to assess the effects of beta-adrenergic blockers, propranolol and pindolol on the immune response in immunized mice with sheep red blood cells (SRBCs), also they were com­pared with hydrocortisone as a stan­dard immuno-suppressive agent and all were compared with immunized control mice. The test drugs have dif­ferent pharmacological properties to declare if these different properties

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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