Article Type
Article
Abstract
Recently Seegers et al, (1979) reported that concurrent administration of paracetamol with aspirin resulted in decreased gastric acidity indueed by aspirin in rats, this effect is due to stimulation of endogenous production of prostaglandins produced by paracetamol. The work of Seegers et al. (1979) was based on the observations of Bobak et al. (1978) and Me Donald et al., (1979) that paracetamol could stimulate the prostaglindin sythetase of bovine seminal vesicles in vitro. The antagonism of paractamol to the gastric hyperacidity, may be accompanied by an antagonism to the therapeutic efficacy of aspirin but, on the other hand, paracetamol has pharmacological properties which are similar to those of aspirin and might there-forefore augment the therapeutic efficacy. In the present work the inter-177 action between paracetamol and aspirin with regard to their analgesic and anti anflammatory activities were studied in rats.
Recommended Citation
Abd El - Hamid, M.A.
(1990)
"EFFECT OF INTERACTION BETWEEN FUROSEMIDE AND OXYTERCYCLINE ON BLOOD UREA AND CREATININE IN RATS,"
Mansoura Medical Journal: Vol. 19
:
Iss.
1
, Article 18.
Available at:
https://doi.org/10.21608/mjmu.1990.138854
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