EVALUATION OF SERUM MELATONIN IN THYROID DISORDERS

Authors

Mohamad Said, Medical Biochemistry' and General Surgery" Departments, Faculty of Medicine, Mansoura University, Egypt
Mohamad Abd-Ellatif, Medical Biochemistry' and General Surgery" Departments, Faculty of Medicine, Mansoura University, Egypt
Mosaad Soliman, Medical Biochemistry' and General Surgery" Departments, Faculty of Medicine, Mansoura University, Egypt

Article Type

Original Study

Abstract

In order to evaluate the pineal-thyroid-pituitary interaction, the serum melatonin concentration was estimat­ed in 45 age and sex matched sub­jects: 20 with hyperthyroidism, 12 with hypothyroidism and 13 with euthyroid function. Serum melatonin as well as serum ts, 14, and TSH were deter­mined by enzyme immunoassay. A significant decrease in serum melato­nin was observed in hyperthyroid pa­tients whereas there was a significant increase of serum melatonin in hypo-thyroid patients. Also, there was a sig­nificant negative correlation between serum melatonin and serum T4 in all subjects. On the other hand, there was a significant positive correlation between serum melatonin and serum TSH in euthyroid idividuals. In conclu­sion our study demonstrated that pa­tients with hyperthyroidism secrete less melatonin than euthyroid sub­jects and this observation may help in ameliorating the anxiety symptoms that accompany thyrotoxicosis.

Recommended Citation

Said, Mohamad; Abd-Ellatif, Mohamad; and Soliman, Mosaad (2000) "EVALUATION OF SERUM MELATONIN IN THYROID DISORDERS," Mansoura Medical Journal: Vol. 29 : Iss. 1 , Article 11.
Available at: https://doi.org/10.21608/mjmu.2000.126815

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