Article Type
Article
Abstract
Tumor necrosis factor - alpha (TNF-a) is a pleiotropic cytokine derived from activated macrophages and other cells, and proved to have tremendously diverse functions. Long term experimental diabetes has been found to be associated with enhanced serum TNFa activity. We attempted to study the serum TNF-a levels in insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM) patients, to find out any possible correlation between TNF-a levels and the duration of diabetes, and abnormalities of serum lipid pattern. This study was performed on non-smoker male subjects comprising three groups. Group 1 included 33 IDDM patients, group 2 included 30 NIDDM patients and group 3 included 25 healthy control individuals. All patients and control subjects were age matched and selected from the attendants of the Outpatient Clinic of Internal Medicine Department, Mansoura University Hospital. The results of the present study revealed a significant increase of total cholesterol, LDL cholesterol and tri-glycerides levels in diabetic patients compared to control group, and a significant increase of triglycerides levels in IDDM compared to NIDDM patients.
Recommended Citation
Abd Ellatif, Mohamad; Said, Mohamad; and Yossof, Mahmoud
(2000)
"STUDY OF CIRCULATING TUMOR NECROSIS FACTOR-ALPHA: RELEVANCE TO INSULIN- DEPENDENT AND NON INSULIN-DEPENDENT DIABETES MELLITUS,"
Mansoura Medical Journal: Vol. 29
:
Iss.
1
, Article 12.
Available at:
https://doi.org/10.21608/mjmu.2000.126817
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
