Article Type
Original Study
Abstract
This study included 20 atopic dermatitis patients (AD) (11 males and 9 females) 10 mild and 10 severe cases as well as 20 Psoriatic patients (10 males and 10 females) 10 mild and 10 severe cases, this besides 20 healthy control subjects of matched age and sex. None of these patients had received any systemic medications for at least 3 months prior to the study. Only emollients were applied as topical treatment during a 2-week washout period. B-Endorphin concentration was done on separated plasma samples from patients and controls using RIA principle. While the hormonal assay (cortisol, PRL, T4, TSH, PTH) were performed on sera of patients and controls using automated chemilumin-scent enzyme immunoassay principle. B-Endorphin concentration was increased in AD and psoriatic patients when compared to controls. The level of B-endorphin correlates with the disease severity. B-endorphin concentration was significantly increased in psoriatic patients vs AD patients. Stress had nonsignificant effect on B-endorphin concentration in AD and psoriatic patients. While the level of cortisol and PRL were significantly increased in stressed AD and psoriatic patients vs controls as well as non-stressed patients. The level of T4, TSH and PTH showed nonsignificant change by stress. Cortisol level was found to be higher in psoriatic patients vs AD patients and controls.
Recommended Citation
Monib, Khaled; Wadea, Nancey; Amin, Amal; and Marzouk, Hamdy
(2000)
"Evaluation of B-endorphin concentration in Atopic Dermatitis and Psoriatic patients,"
Mansoura Medical Journal: Vol. 29
:
Iss.
1
, Article 13.
Available at:
https://doi.org/10.21608/mjmu.2000.126819
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