Article Type

Original Study


Objective : 1- To determine if there is any charactcrctistic cerebral morphological abnormalities in cirrhotic children with subclinical hepatic encephalopathy,2- To find if there is any correlation between hepatic function derangement and cerebral morphology. Patients and Methods: 24 children with inactive cirrhosis (fifteen male and nine female) with age range five - fifteen years, and twenty controls with matched age and sex were studied. 10 different CT Parameters and 5 psychometric tests have been evalu­ated for patients and controls. El (Evan index) and MWT (Maximum width of 3ro< ventricle) were statistically higher in patients than controls (P<0.02, P<0.02). CT changes were both specific and focal. Prothrombin time was only correlated with MWT and WXF (Wechsler Forward) (P<0.01, P<0.006). Multiple re­gression analysis revealed that WXF and El were the most impor­tant predictors for grouping (P<0.004, P<0.045). Conclusions : Quantification of CT Scan abnormalities has been shown to yield valuable information about the morphology of the brain that in otherwise not detectable upon subjective visual inspection alone. Subclinical hepatic enceph-lopathy is not a neuropsychatric disease characterized by metabolic dysfunction alone, but may also involve gross cerebral morphological alterations.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.