Article Type
Original Study
Abstract
In so-called anesthetic doses, all benzodiazepines decrease blood pressure and increase heart rate secondary to a decrease in peripheral resistance. But exceptionally, with dia-zepam they are reported to be secondary to a decrease in left ventricular work and cardiac output. This study was conducted to determine the effect of diazepam in subanesthetic dose on the different phases of cardiac work; the rapid, reduced ejection phases of ventricular systole and on the arterial pressure decay after aortic vaive closure. These phases of cardiogram were recognized and analyzed using a computer system connected to two biopreamplifiers for arterial pressure and ECG monitoring simultaneously. Single arterial pressure wave could be magnified for doing different estimations for the different phases of the arterial pressure wave. Two groups of rabbits, each of 6 animals were used to test the effect of diazepam (0.7 mg /rabbit i.v) and the blocking or reversing effects induced by flumazenil (0.02 mg /rabbit i.v.). Each animal served as a control for itself. Diazepam and not flumazenil decreased the ejection period as compared with that of control {0.56±0.09 Vs 1.00±0.09 msec). This effect was not accompanied by any change in heart rate and cardiac cycle period. Flumazenil blocked this diazepam effect but insignificantly reversed it. Increased ejection velocity by diazepam was indicated by an increase in the ascending limb slope of the arterial pressure wave (0.6060±0.0367 Vs 0.4845±0.0279) together with unchanged pulse pressure.
Recommended Citation
Saad, Mohamed and Mageed, Nabil
(2000)
"CARDIOGRAM PATTERN AFTER SEDATIVE DOSE OF DIAZEPAM IN RABBITS,"
Mansoura Medical Journal: Vol. 29
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2000.126958
Creative Commons License
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