Article Type

Original Study


Leptin is reported to have effects on peripheral tissues that are inde­pendent of its centra! effects on food intake and body weight. In this study we examined the chronic effects of leptin injection on some lipid metabol­ic parameters, glucose handling by the body tissue and glycogen content in liver and skeletal muscles in lean and obese rats. Rats were divided into 2 groups (20 rats each) one group included lean rats and the other included diet induced obesity (DIO) rats. Ten rats of each group were in­jected intraperitoneal with leptin in a dose of (7.2 ngm/gm/day) for 2 weeks. The other rats served as con­trol groups. In all rats, body weight non estrified fatty acids (NEFA), trigly-cerides (TG), glucose tolerance, mus­cle and liver glycogen were meas- ured. Results revealed that, in lean rats, body weight was decreased, with increased serum non-estrified fatty acids (NEFA), without improvement in glucose tolerance, and without change in liver or muscle glycogen content. In obese rats, body weight decreased, serum insulin level de­creased, with increased serum NEFA and triglycerides (TG). Improvement in glucose tolerance with decreased liver and muscle glycogen content was observed. These data indicate that leptin induces a complex meta­bolic responses with effects on glu­cose as well as lipid metabolism which are independent of central ner­vous system. It could be concluded that artificial elevation of serum leptin stimulates lipolysis and inhibits glu­cose storage as glycogen in the liver and skeletal muscles.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.