Article Type
Original Study
Abstract
Insulin resistance or compensatory hyperinsulinemia has been associated with dyslipidemia. Tumour necrosis factor-( (TNF-ci) may be an important circulating cytokine which may provide a potentially reversible mechanism for mediating insulin resistance. The present study was carried out to compare the be. ^ricial effect of either the oral antidiabetic (metformin) or the angiotensin converting enzyme inhibitor (captopril) on insulin sensitivity in rats fed high-fructose diet for 9 weeks. Other contribution of this work is to find if the improving effect of metformin or captopril on insulin resistance occurs through modulation of TNF-cx or not. 108 male albino rats were used throughout this study. The animals were divided into 6 equal groups (n=18). Group (1) served as a control received standard diet for 9 weeks. Group (2) received high fructose diet for 9 weeks. Group (3) received standard diet for 9 weeks and metformin treatment in a dose of 200 mg/kg/day in the last 3 weeks. Group (4) received high fructose diet for 9 weeks and metformin treatment in the last 3 weeks. Group (5) received, standard diet for 9 weeks and captopril treatment in a dose of 2 mg/kg/day in the last 3 weeks. Group (6) received high fructose diet for 9 weeks and captopril treatment in the last 3 weeks. Insulin sensitivity test, intravenous glucose tolerance test (IVGTT), fasting serum insulin were all used to determine insulin sensitivity. In addition lipogram
Recommended Citation
Mokbel, Somaia A. and Abdel Rahman, Karawan M.
(2001)
"COMPARATIVE STUDY OF METFORMIN AND CAPTOPRIL ON INSULIN SENSITIVITY IN HIGH-FRUCTOSE FED RATS,"
Mansoura Medical Journal: Vol. 30
:
Iss.
1
, Article 11.
Available at:
https://doi.org/10.21608/mjmu.2001.127008
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
