Article Type

Original Study


Background: In Patients with chronic renal failure (CRF), metabolic bone disease is a common complica­tion. Osteopenia is frequently report­ed in adult CRF patients, and after transplantation. However, reports on bone mineral density (BMD) and bone metabolism in children are rather sparse. Objective: The aim of this work was to study BMD in a group of chil­dren with end-stage renal failure, and to relate their BMD to some markers of bone metabolism. Methods: Measurements of serum calcium, phosphorus, alkaline phos-phatase (AP), calcitonin (CT) and par­athyroid hormone (PTH) were per­formed in 25 children aged 9.85±3.44 years with end-stage renal failure (11 males and 14 females), and in 15 age and sex matched controls. Measure­ment of bone mineral density (BMD) was performed for patients and con­trols using quantitative computed to­mography. Results: Our results showed that serum calcium was significantly lower, while serum levels of phosphorus and AP were significantly higher com­pared with controls. Plasma CT levels were significantly higher in CRF pa­tients in comparison to controls (29.7±7.3 vs 13.8±4.1pg/ml, p < 0.01). PTH levels were significantly higher in CRF patients compared with controls {413.7+113.4 vs 12.1+6.1, p < 0.0001). BMD was slightly lower in CRF pa­tients compared with controls (141.2±26.5 vs 150.3±33.5 gm/cm3), but the difference was not statistically significant. These parameters did not differ significantly between patients undergoing hemodialysis and those

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.