Article Type
Original Study
Abstract
OBJECTIVE : To analyse the initial manifestations, pathological findings, therapy, outcome and prognostic factors in patients with papillary and follicular carcinoma of the thyroid gland and also to evaluate DNA flow-cytometry as a prognostic factor in dif-frentiated thyroid carcinoma. PATIENTS : Analysis of clinical and pathological records was conducted on 210 patients { 48 male and 162 female) treated for well differentiated thyroid carcinoma refered to Clinical Oncology Department and Surgical Endocrinology Unit, Mansoura University Hospital in the period from Janury 1990 to December 1995. RESULTS : The patients were 22.8% males and 77.2% females. 68.6% patients presented with papillary carcinom a. High incidence in fifth decade. 89.5% of cases the duration of symptoms was less than 6 months. 21% presented with neck node metastases, while distant meta-stases in 13% . Recurrences were recognised in 7% of patients. The two and five years disease free survival rates were 91% and 88% respectively. By univariate analysis, patienti's age at the time of diagnosis, tumour size, extraglandular extension, nodal status, distant metastasis were found to be significant prognostic variables while the sex and histology were found to be non significant. DNA content was diploid in 57% of follicular carcinoma and 37% of papillary carcinoma. Aneuploid pattern was
Recommended Citation
H. Sakr, Hanem; A. El-Shahat, Ahmed; Allam, Magda; Fouda, mona; Mostafa, Amal; Abd-Ellattef, Atef; and Ali, Yasser
(2001)
"PROGNOSTIC FACTORS AND RISK GROUPS ANALYSIS IN PATIENTS WITH DIFFERENTIATED THYROID CARCINOMA,"
Mansoura Medical Journal: Vol. 30
:
Iss.
2
, Article 5.
Available at:
https://doi.org/10.21608/mjmu.2001.127026
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This work is licensed under a Creative Commons Attribution 4.0 International License.
