ANTRAL GASTRIN CELL IN HELICOBACTER ASSOCIATED GASTRITIS : QUANTITATIVE IMMUNOHISTOCHEMICAL STUDY

Authors

IBRAHIM HASSAN ALZAHRANI, Consultant Pathologist & Assistant Professor Department of Pathology Faculty of Medicine King Abdulaziz University Jeddah, Kingdom of Saudi Arabia

Article Type

Original Study

Abstract

The number of antral gastrin cells (G cells) and their immunostaining pattern was evaluated in 28 gastro-scopic biopsies without evidence of Helicobacter pylori organisms (HPOS) as a control group, and 42 gastro-scopic biopsies with evidence of HPOs as a test group. There was no significant difference in number of G cells per gland in relation to the pres­ence or absence of HPOs, degree of inflammation, type of gastritis and ac­tivity of inflammation (P>0.05). The intensity of immunostaining of G cells was stronger in association with HPOs positive group (++) than the negative group (+). The intensity of G cell staining was not affected by the severity of infection of HPOs. The in­tensity of immunostaining of G cells was higher in active than quiescent gastritis especially when associated with HPOs. The degree of gastritis has a direct effect on the intensity of immunostaining of G cells especially when associated with HPOs.

Recommended Citation

ALZAHRANI, IBRAHIM HASSAN (2002) "ANTRAL GASTRIN CELL IN HELICOBACTER ASSOCIATED GASTRITIS : QUANTITATIVE IMMUNOHISTOCHEMICAL STUDY," Mansoura Medical Journal: Vol. 31 : Iss. 1 , Article 6.
Available at: https://doi.org/10.21608/mjmu.2002.127086

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