Article Type
Original Study
Abstract
The objective of this study was to evaluate the impact of hypertension on endothelial function. Essential hypertension is an important risk factor for atherosclerosis and endothelial dysfunction is the earliest event in atherogenesis because endothelium play an important role in the modulation of vascular tone by releasing EDRF identified as nitric oxide. We assessed endothelial function in 48 subjects (12 hypertensive and their 12 normotensive siblings with their control groups). B-mode ultrasonography was used to measure the diameter of the brachial artery, endothelium-dependent dilatation was assessed as the change in diameter of the artery during reactive hyperemia (flow mediated dilatation FMD). FMD was less in patients with hypertension (0.055±0.035) than their control (0.113±0.017) (P<0.001). Also FMD was less in the hypertensive siblings (0.109±00.019) than their control (0.19±0.039) (P<0.001). These results indicate that hypertensive patients had decreased FMD of brachial artery during reactive hyperemia, a finding which also present in their siblings although in normotensive range
Recommended Citation
Hatata, El-Sayed Zaki and Amer, Talal
(2002)
"FLOW MEDIATED DILATATION IN HYPERTENSIVE PATIENTS AND THEIR SIBLINGS,"
Mansoura Medical Journal: Vol. 31
:
Iss.
1
, Article 7.
Available at:
https://doi.org/10.21608/mjmu.2002.127087
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This work is licensed under a Creative Commons Attribution 4.0 International License.
