MEDULLARY THYROID CARCINOMA: IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDY

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Article Type

Original Study

Abstract

Eleven cases of medullarly thyroid carcinomas (MTC) were evaluated in relation to the pattern, immunohisto-chemistry and electron microscopy. Six cases were classified as classical MTC with histochemical evidence of amyloid and 5 cases were atypical without histochemical evidence of am­yloid . Immunostaining for thyrocalcit-onin was positive in 4 out of 6 classi­cal and 2 out of 5 atypical MTC cases. The neurosecretory granules were found in both the typical and the atypical MTC cases. The ultrastructu-ral examination is essential in the di­agnosis of MTC particularly where the histological and immunohistochemical evaluation is inconlusive. ABSTRACT Eleven cases of medullarly thyroid carcinomas (MTC) were evaluated in relation to the pattern, immunohisto-chemistry and electron microscopy. Six cases were classified as classical MTC with histochemical evidence of amyloid and 5 cases were atypical without histochemical evidence of am­yloid . Immunostaining for thyrocalcit-onin was positive in 4 out of 6 classi­cal and 2 out of 5 atypical MTC cases. The neurosecretory granules were found in both the typical and the atypical MTC cases. The ultrastructu-ral examination is essential in the di­agnosis of MTC particularly where the histological and immunohistochemical evaluation is inconlusive.

Recommended Citation

(2002) "MEDULLARY THYROID CARCINOMA: IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDY," Mansoura Medical Journal: Vol. 31 : Iss. 1 , Article 8.
Available at: https://doi.org/10.21608/mjmu.2002.127088

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