Article Type
Original Study
Abstract
Purpose: Breast - Conserving surgery (BCS) has generally been limited to T1 and T2 lesions because it has been thought impossible to achieve good local control with satisfactory cosmesis in patients with more advanced disease . However, many patients with 13 and 14 lesions will exhibit dramatic tumor downstaging with neoadjuvant Chemotherapy. It is our hypothesis that for these patients BCS can be performed with good local control and cosmesis. Material and Methods : Between February 1999 and Jan 2003, 34 patients with 13/14, NO-N2 . M0 breast cancer completed treatment consisting of 4 Courses of (FAC) 500 mg Cyclophosphamid / m2, 50 mg/ m2 of doxorubicin, 500 mg fluoroura-cil every 3 weeks, Surgery (a local excision if sufficiently downstaged, or mastectomy if not) Followed by another 3 courses of FAC and post radiation therapy. Patients were evaluated for toxicity, local control, cosmesis, disease - free and overall survival. Results : Median follow-up is 30 months. 15/34 (44%) patients underwent BCS with only one local - regional failure and actuarial 3- years disease - free and overall survival of 77% and 88%. Cosmetic results were good to excellent in 80% of the patients. Conclusion : These results suggest that with this regimen a subset of patients with locally advanced breast cancer can preserve their breast with acceptable cosmesis without compromising local control or survival.
Recommended Citation
Megahed, Abdel-Salam and El-Hendawy, El-Sayed '
(2003)
"BREAST-CONSERVING TREATMENT IN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER,"
Mansoura Medical Journal: Vol. 32
:
Iss.
1
, Article 1.
Available at:
https://doi.org/10.21608/mjmu.2003.127200
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