Article Type

Original Study


We describe a case of 61-year-old man presented with multiple constitu­tional symptoms and found to have si­multaneous occurrence of acute myeloblastic leukemia (AML-M4) and Hodgkin's lymphoma in the cervical lymph node. Peripheral blood (PB) and bone marrow (BM) smears showed typical AML-4 features. Kar-yotyping of the bone marrow revealed many cytogenetic changes including t(16;17) and -Y. SKY analysis show the following clonal pattern 42,X,-Y,der(2)t(2;11)(q37;?), der(5;17) (p10;p10), der(16)t(16;21) (q24;q11),-18, -21. To prove that the Hodgkin's lymphoma of the cervical lymph node is not a leukemic infiltrate and that it is from different clone, interphase flu­orescence in situ hybridization (IFISH) was applied on the lymph node biop­sy using X and Y centrosome probes revealed absence of loss of chro­mosome Y. These findings indicated that this patient had a coexistence of AML and Hodgkin's lymphoma. Up to our knowledge this is the first cytogenetically proved case report of a simultaneous occurrence of these two diseases. CLINICAL HISTORY: The patient was a 61-year-old man presented with multiple costitutional symptoms including weight loss, shortness of breath, night sweat and fever. On admission he was found to

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.