Article Type
Original Study
Abstract
Insulin resistance is known to be a risk factor for the development of type II diabetes mellitus, cardiovascular diseases associated with dyslipidemia & obesity. The present work aimed at the investigation of the influence & possible mechanism of either pravastatin or captopril on contractile response of the isolated aortic strip to noradrenaline (NA) in rats with established insulin resistance induced by high fructose diet Furthermore to our knowledge there is no study comparing the effect of pravastatin & captopril as regarding the biochemical changes associated with insulin resistance in rats. The present study was carried out on fourty-eight male albino rats. Rats were divided into 2 main groups:Group (A); consisted of 12 animals that received standard diet through the experiment {8 weeks) & treated with intragastric saline (the vehicle), starting from the last 2 weeks of experiment & served as normal control. Group (B); consisted of 36 animals, received high fructose diet (for 8 weeks) for induction of insulin resistance. This group was subdivided into 3 equal subgroups (12 rats / subgroup ) as the following: subgroup (b1); served as insulin resistant control, treated with saline, subgroup (b2); insulin resistant rats treated with pravastatin in a dose of 20 mg/kg/day, intragastrically in the last 2 weeks of the experiment, subgroup (b3): received high fructose diet (insulin resistant) & treated with captopril in a dose of 2 mg/kg/day intragastrically in the last 2 weeks of the experiment.
Recommended Citation
Mokbel, Somaia A. and Abdel Rahman, Karawan M.
(2003)
"COMPARATIVE STUDY OF THE EFFECT OF PRAVASTAT1N AND CAPTOPRIL ON THE CONTRACTILE RESPONSE OF ISOLATED AORTIC STRIP TO NORADRENALINE IN HIGH FRUCTOSE-FED ALBINO RATS.,"
Mansoura Medical Journal: Vol. 32
:
Iss.
1
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2003.127201
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
