Article Type
Original Study
Abstract
Cardiac functions are controlled by higher brain centers and sympathetic and parasympathetic nervous systems, which act via adrenergic and muscarinic receptors respectively, Cardiac baroreceptor, renal barore-ceptors and arterial baroreceptors influence reflexly the activity of cardiovascular autonomic nerves. The potent loop diuretic furosemide is used for rapid relief of acute pulmonary edema due to acute left sided heart failure and congestive heart failure. So the present work was conducted to evaluate the effect of single intravenous dose of furosemide on cardiac autonomic activity in rabbits. Seventy-two rabbits were randomly divided into three equal major groups with different autonomic states; one with intact autonomic components, the second with blocked parasympathetic components (0.2 mg/kg I.V. atropine), the third with blocked sympathetic (1 mg/kg I.V. atenolol). Each major group include four subgroups; control (non furosemide treated with intact kidneys; furosemide treated with intact kidneys; non furosemide treated binephrectomized) and furosemide treated binep-hrecto-mized. Binephrectomized grou-ps allow the assessment of furosemide autonomic activities independent of furosemide renal effects. Our data demonstrate modulation of cardiac baroreceptor reflexes activity by furosemide that is independent of furosemide renal effects. However, furosemide had no effect on isolated rabbit heart. Also, we found that furosemide induced an activation of tonic
Recommended Citation
E.M.M, Elkholi; MAA, Saad; Abd-EI Rahman, Karawan M; and A.M.H, Ead
(2003)
"EFFECT OF SINGLE INTRAVENOUS DOSE OF FUROSEMIDE ON CARDIAC AUTONOMIC ACTIVITY IN RABBITS,"
Mansoura Medical Journal: Vol. 32
:
Iss.
1
, Article 6.
Available at:
https://doi.org/10.21608/mjmu.2003.127205
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