INVESTIGATION OF THE PROGNOSTIC AND PREDICTIVE VALUE OF NM23 (ANTIMETASTATIC GENE PRODUCT) AND KI-67 IN SAUDI PATIENTS WITH COLORECTAL CARCINOMA: AN IMMUNOHISTOCHEMICAL ANALYSIS

Authors

Jaudah Al-Maghrabh, Department of Pathologyl, Faculty of Medicine, King Abdulaziz university, King Abdulaziz University Ho$pital2, Jeddah, Saudi Arabia.

Article Type

Original Study

Abstract

BACKGROUND : Expression of nm23 has been shown to be inversely correlated with the metastatic poten­tial of several human cancers. The objective of this study is to evaluate the value of nm23, and Ki-67 as prog­nostic markers in patients with color-ectal carcinoma METHODS: We conducted a ret­rospective analysis on 56 patients with colorectal carcinoma. Immuno-histochemistry (IHC) was performed on archival formalin fixed paraffin em­bedded sections. Antibodies to nm23 and Ki-67 were used. This was corre­lated with the following clinicopatho-logic parameters: patient sex, age and survival, stage, and grade of the tumors. i":v " RESULT: Among the 56 cases of colorectal cancer there were 24 fe­male and 32 male. (Male/female=1.3). The mean age was 54.9 years (range 30-80 years). Two of the cases were Dukes' stage A, 28 (stage B), 18 (stage C) and 8 (stage D). Ki-67 was positive in 94%(n=53). The positivity in different stages was as follows (2/2 stage A, 26/28 stage B, 17/18 stage C and 7/8 stage D), Normal mucosa ad­jacent to cancer showed positive staining for ki-67 in 18/56. nm23 was positive in 84% (n=47) of tumors com­pared to 45/56 of normal mucosa. The positivity in different stages

Recommended Citation

Al-Maghrabh, Jaudah (2003) "INVESTIGATION OF THE PROGNOSTIC AND PREDICTIVE VALUE OF NM23 (ANTIMETASTATIC GENE PRODUCT) AND KI-67 IN SAUDI PATIENTS WITH COLORECTAL CARCINOMA: AN IMMUNOHISTOCHEMICAL ANALYSIS," Mansoura Medical Journal: Vol. 32 : Iss. 2 , Article 1.
Available at: https://doi.org/10.21608/mjmu.2003.127235

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