Article Type
Original Study
Abstract
Infection with hepatitis C virus has elicited considerable interest for its role in a spectrum of extrahepatic manifestation. Substantial evidence has implicated a causative role for hepatitis C virus (HCV) in many Of skin diseases. This study was conducted to estimate the prevalence of HCV infection and cryoglobulinaemia in patients with leukocytcclastic vasculitis {LcV} and to assess the immunologic changes associated with this disease. The present study included 39 adult patients (14 males and 25 females, with mean age of 44.1±12.1 years) had LcV and 40 adult heaithy controls. All patients were subjected to thorough history taking, clinical examination abdominal ultrasound and full laboratory investigations including urine and stool analysis, complete blood picture, liver function tests, kidney function tests and pro-thrombine time. HCV antibodies were determined by third-generation ELISA then polymerase chain reaction (PCR) was performed on seropositive cases in test group and controls. Assay of tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and soluble IL-2 receptor (slL-2R) and soluble intercellular adhesion molecule-1 (slCAM-1) were performed. The prevalence of HCV antibodies was 46.2% in LcV patients versus 17.5% of the controls. However with PCR reaction 38.5% of LcV patients
Recommended Citation
El-Adrosy, Hala; Fathy, Hanan; El-Mashad, Noha; and Abd-EI-Samea, Elham R.
(2003)
"LEUKOCYTOCLASTIC VASCULITIS: PREVALENCE OF HEPATITIS C VIRUS, CRYOGLOBULINAEMIA AND EVIDENCE OF IMMUNOLOGIC ACTIVATION,"
Mansoura Medical Journal: Vol. 32
:
Iss.
2
, Article 11.
Available at:
https://doi.org/10.21608/mjmu.2003.127250
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This work is licensed under a Creative Commons Attribution 4.0 International License.
