Article Type
Original Study
Abstract
This study was designed to evaluate hemodynamic and neuromuscular blocking effects of different doses of pipecuronium and atracurium combination. Sixty patients of either sex were included in this study.The patients were scheduled for major abdominal surgery and they were classified into three groups (each of 20).Acccrding to muscle relaxant given .-Group (A) received 0.08 mg /kg pipecuronium alone and Group (B) received a combination of pipecuronium and atracurium in a dose of 0.04 and 0.25 mg/kg respectively .Group (C) received the same combination but in a dose of 0.026 and 0.166 mg/kg respectively .Ail the patients were pre-medicated with 0.03 mg/kg midazo-lam and maintenance of anesthesia was done by N2O in oxygen (2:1) and isoflurane 1:1.5 %. Neuromuscular monitoring including onset of action of muscle relaxant .assessment of intubation condition using intubation condition score,duration of bolus dose, number of redoses, duration of each, recovery times and total dose of muscle relaxant. Combination of both pipecuronium and atracurium in half the intubating dose (group B) produced clinical effective neuromuscular blockade with acceptable onset time similar to that of pipecuronium alone, and the duration of clinical relaxation of the first redose displayed a potentiating affect. The clinical duration and recovery times of the combined drugs in group C were shorter than those of A &B
Recommended Citation
El-Kharboutly, Walaa S.; Wahba, Ashraf; Hussein, Samy; and Rashad, Aly
(2003)
"EVALUATION OF NEUROMUSCULAR PROFILE OF PIPECURONIUM AND ATRACUR1UM COMBINATION,"
Mansoura Medical Journal: Vol. 32
:
Iss.
2
, Article 9.
Available at:
https://doi.org/10.21608/mjmu.2003.127246
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