Article Type
Original Study
Abstract
Polycythemia vera is a clonal disorder originating in a pluripotent he-matopoietic stem cells. Nephrotic syndrome is a clinical complex characterized by a number of renal and extra renal features, the most prominent of which are proteinu-ria (>3.5 g per day), hypoalbumine-mia, oedema, hyperlipidemia and hy-percoagulability. The target defect is altered permeability of the glomerular filtration barrier for protein leading to glomerular proteinuria. Primary renal disorders account for most of the cases. Common systemic disease associated with nephrotic syndrome includes diabetes mellitus, systemic lupus erythematosus, amyloidosis and multiple myeloma. We describe a case of nephrotic syndrome due to focal segmentai glomerulosclerosis (FSGS) associated with myeloprolifer-alive disease (MPD). The association between MPD, including polycythemia vera and nephrotic syndrome has been described in case reports and case series. Secondary causes for nephrotic syndrome were excluded. We speculate that the casual relationship between the two diseases is very likely. Possible causes postulated in literature are discussed. However, the exact patho-physiologic basis remain to be confirmed.
Recommended Citation
Sayes, Fatin; Shohaib, Saad; and Almalki, Abdullah
(2004)
"FOCAL SEGMENTAL GLOMERULOSCLEROSIS ASSOCLTED WITH MYELOPROLIFERATIVE DISORDER,"
Mansoura Medical Journal: Vol. 33
:
Iss.
1
, Article 9.
Available at:
https://doi.org/10.21608/mjmu.2004.127435
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
