Article Type

Original Study


Polycythemia vera is a clonal dis­order originating in a pluripotent he-matopoietic stem cells. Nephrotic syndrome is a clinical complex characterized by a number of renal and extra renal features, the most prominent of which are proteinu-ria (>3.5 g per day), hypoalbumine-mia, oedema, hyperlipidemia and hy-percoagulability. The target defect is altered permeability of the glomerular filtration barrier for protein leading to glomerular proteinuria. Primary renal disorders account for most of the cas­es. Common systemic disease asso­ciated with nephrotic syndrome in­cludes diabetes mellitus, systemic lupus erythematosus, amyloidosis and multiple myeloma. We describe a case of nephrotic syndrome due to fo­cal segmentai glomerulosclerosis (FSGS) associated with myeloprolifer-alive disease (MPD). The association between MPD, in­cluding polycythemia vera and neph­rotic syndrome has been described in case reports and case series. Secon­dary causes for nephrotic syndrome were excluded. We speculate that the casual relationship between the two diseases is very likely. Possible caus­es postulated in literature are dis­cussed. However, the exact patho-physiologic basis remain to be confirmed.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.