Article Type
Original Study
Abstract
Stroml changes may play an important role in progression, invasion and prognosis of colorectal tumors. Biopsy specimens of colorectal tumors were evaluated for stromal characterizations. Section stained with Haematoxyline and eosin (H&E) were examined as regard the presence of tumor infiltrating lymphocytes (TILs) and tumor associated eosinophilic infiltrate (TE). The number of TILs were larger in earliest stages of colorectal cancers and decreased with the presence of metastasis. The prognosis of carcinomas was better for those with higher eosinophilic infiltration. Expression of gelatinaseA type of Matrix Metalloproteinases (MMP2) was assessed histochemically in both adenomas and carcinomas. Cytoplasmic expression of MMP-2 is significantly high in colorectal carcinomas (56%) compared to adenomas (20%).{ p=0.006}. A positive relationship between MMP-2 expression and tumor grade, Dukes' stage and nodal status was reported.. The staining intensity of MMP-2 in adenomas was either moderate (50%) or weak (50%). On the other hand, 28.6% of carcinomas were strongly stained, 39.3% were moderately stained and 32.1% were weakly stained.
Recommended Citation
Amin, Maha; El-Baz, Mahmoud; Fawzy, Mohamed; and Abdel-Hafez, Amal
(2003)
"SOME HISTOCHEMICAL STROMAL CHARACTERIZATIONS IN COLORECTAL EPITHELIAL TUMORS,"
Mansoura Medical Journal: Vol. 33
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2003.127465
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
