Article Type
Original Study
Abstract
Background : Thrombopoietin (TPO) is an important regulator of megakaryocyte maturation and platelet production. The role of TPO (which is mainly produced by the liver) in thrombocytopenic cirrhotic patients is still under investigation. The aim of this study was to measure the serum TPO levels in cirrhotic patients and examine its relationship with circulating platelet count, splenic size and clinical stage of liver cirrhosis. Study design and methods : This study was conducted on 88 subjects, divided into 2 groups, group I (patient group} included 72 patients with liver cirrhosis (diagnosed by combination of clinical, laboratory, uitrasouna and histopathological data), they were fur- ther divided into 2 subgroups, group IA: included cirrhotic patients with thrombocytopenia (36 patients, 28 males and 8 females with age 50.3±8.5 years), and group IB: included cirrhotic patients with normal platelet count (36 patients, 26 males and 10 females, with age 50.64±6.8 years). Group II comprised 16 healthy persons with matched age and sex, used as a control group. Ail included persons were subjected to: thorough history taking, full clinical examination, beside the following investigations: complete blood picture, kidney and liver function tests, Hepatitis B and C markers, serum TPO level (by sensitive sandwich ELISA) and abdominal Doppler ultrasound. The following invasive investigations were
Recommended Citation
El-Sayed, Sayed Salem; Askalany, Hassan; Abdel-Khalek, Ehab; Amin, Tarek; Awad, Mohamed; and EI-Nahas, Mahmoud
(2003)
"SERUM THROMBOPOIETIN LEVELS IN PATIENTS WITH LIVER CIRRHOSIS; RELATION TO SEVERITY OF THE DISEASE, SPLEEN SIZE AND PLATELET COUNT,"
Mansoura Medical Journal: Vol. 33
:
Iss.
2
, Article 6.
Available at:
https://doi.org/10.21608/mjmu.2003.127470
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