THE PROTECTIVE ROLE OF ANTI-OXIDANT BETA-CAROTENE ON SCHISTOSOMA MANSONI INFECTED MUR1NE MICE

Authors

Saed Ruzik, Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University
Saleh Alebiary, Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University
Mohamed Bastawy, Tropical Medicine Department, Cairo Faculty of Medicine, AL-Azhar University
Mostafa Abou Alnga, Anatomy and Emberyology Department, Damietta Faculty of Medicine, AL-Azhar University
Samy Zaky, Tropical Medicine Department, Damietta Faculty of Medicine, AL-Azhar University5
Nabil AInoamani, Tropical Medicine Department, Damietta Faculty of Medicine, AL-Azhar University5
Mohamed Hishmat, Parasitology Department, Medical Research Institute,Alexandria University
Mohamed Tawfik, Tropical Medicine Department, Beni-Suef Faculty of Medicine, Cairo University
Ashraf Z. EI-Sayed, Zoology Department, Faculty of Science, Al-Azhar University

Article Type

Original Study

Abstract

Schistose mi as is is the second most prevalent tropical disease in the world after malaria and is caused by the Schistosoma, genus of fluke. The pathophysiology of schistosomiasis is due to the immune response against the schistosome eggs. The clinical manifestations depend on the species of parasite, intensity of worm burden, and immunity of the person to the parasite. Many trials were done for production of vaccine against infec­tion of shistosomiasis and many ef­forts were spent to prevent infection, but the rate of new cases is still high. On the other hand, we need a meth­od to prevent or at least decrease the inflammatory reaction caused by schistosomiasis. This study aimed to the evaluation of possible protective effect of anti-oxidant b-carotene on S.mansoni infected mice or decrease the inflammatory reaction caused by schistosomiasis. Sixty nice were included in this study and they were divided into 4 groups, every group is 15 mice:Group (1): (treated infected group); Group (2): {treated non-infected group); Group (3): {infected group) and Group (4): (normal con­trol). The results: b-carotene reduced worm burden to about 20%, fa-carotene significantly reduced hepatic and intestinal tissue egg load with a reduction percentage of 26%

Recommended Citation

Ruzik, Saed; Alebiary, Saleh; Bastawy, Mohamed; Abou Alnga, Mostafa; Zaky, Samy; AInoamani, Nabil; Hishmat, Mohamed; Tawfik, Mohamed; and EI-Sayed, Ashraf Z. (2005) "THE PROTECTIVE ROLE OF ANTI-OXIDANT BETA-CAROTENE ON SCHISTOSOMA MANSONI INFECTED MUR1NE MICE," Mansoura Medical Journal: Vol. 34 : Iss. 1 , Article 1.
Available at: https://doi.org/10.21608/mjmu.2005.127744

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