STUDY OF THE EFFECT OF VALSARTAN ON ADJUVANT-INDUCED ARTHRITIS IN ALBINO RATS

Authors

Somaia Mokbel, department of clinical pharmacolog Mansoura Faculty of medicine, Egypt.

Article Type

Original Study

Abstract

The present work was conducted to investigate the influence of valsar-tan (a highly selective antagonist on angiotensin II type-1 receptors (AT^-R blocker) in rats with experimentally - induced inflammation in the form of collagen II- induced adjuvant arthritis. Thirty two, healthy male albino rats were used throughout this study. Rats were divided into 4 equal groups, each comprised 8 rats. The first group consisted of non-arthritic animals (normal control). This group received intra-gastrically normal saline {the ve­hicle used to dissolve drugs), for 2 weeks. The second group consisted of arthritic rats that received intra-gastrically saline for 2 weeks & served as an arthritic control. The third group consisted of arthritic rats treated with indomethacin (non-steroidal anti-inflammatory drug, NSAID) in a daily dose of 1.3 mg/kg for the same previously mentioned duration & by the same route of ad-miniistration. The fourth group con­sisted of arthritic rats treated with a daily intra-gastric dose of valsartan (20 mg/kg) for 2 weeks. It was found that administration of collagen II & complete freund's adju­vant to rats produced a significant arthritic changes as assessed by paw oedema thickness, analgesmetric pressure & C-reactive protein (CRP). Furthermore arthritic rats showed a significant increase in fibronectin (In) & malondialdehyde { MDA) ; an indi­cator of free oxygen radical.

Recommended Citation

Mokbel, Somaia (2005) "STUDY OF THE EFFECT OF VALSARTAN ON ADJUVANT-INDUCED ARTHRITIS IN ALBINO RATS," Mansoura Medical Journal: Vol. 34 : Iss. 1 , Article 11.
Available at: https://doi.org/10.21608/mjmu.2005.128096

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