Article Type
Original Study
Abstract
This study was designed to examine the effects of combined administration of the angiotensin receptor blocker (AT1RB), valsartan & the angiotensin converting enzyme inhibitor (ACEI), ramipril on renal function in rats with liver cirrhosis. This animal model was induced by giving gradually increased intra-gastric doses of carbon tetrachloride (CCI4). - . Thirty male albino rats weighing 150-200 grams were used through this study. Rats were divided as the following: Group (I) : formed of 6 non-cirrhotic control rats. Group (H) : comprised 6 cirrhotic as- citic control rats. Group (III) : Cirrhotic ascitic rats treated with ramipril in a dose of 2.5mg/kg/day for 2 weeks. Group (IV) : Cirrhotic ascitic rats treated with valsartan in a dose of 20mg/kg/day for 2 weeks. Group (V): Cirrhotic ascitic rats treated with ramipril & valsartan combination for 2 weeks. Daily urine volume & body weight were assessed to follow up the development & progress of ascites. Urinary & plasma sodium & potassium were measured. In addition plasma renin activity (PRA) & serum creatinine were estimated. In cirrhotic ascitic rats combination therapy with ramipril & valsartan was more efficacious than either monotherapy in improving kidney function & salt & water retention. Ramipril is as equally effective as valsartan at ameliorating the decline in renal function & salt
Recommended Citation
Abdel Rahman, Karawan
(2005)
"STUDY OF THE RENAL RESPONSE TO RAMIPRIL AND VALSARTAN IN RATS WITH LIVER CIRRHOSIS AND ASCITES,"
Mansoura Medical Journal: Vol. 34
:
Iss.
1
, Article 5.
Available at:
https://doi.org/10.21608/mjmu.2005.127755
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