Article Type
Original Study
Abstract
ABSTRACT This study aimed to evaluate changes in plasma malondialdehyde, total thiol concentration and total anti-oxidant activity in newly diagnosed Graves' disease and toxic multinodu-lar goiter patients prior to antithyroid treatment and after restoration of stable euthyroid state. Forty subjects were included in this study. Thirty patients with hyper-thyroidism, which were classified into two groups, the first (group I) Comprised 15 patients with hyperthyroi-dism due to untreated Graves' disease, and the second (group II) Comprised 15 patients with hyperthyr-oidism due to untreated toxic multi-nodular goiter. Ten patients of each group were treated pharmacologically with antithyroid drug carbimazol (30 mg/day for 8 weeks). Total thyroxin (T4), total triiodothyronine (13), TSH, malondialdehyde, total thiol concentration and total antioxidant activity were estimated before initiation of treatment. After apparent attainment of euthyroid state, all tests were repeated for ten of the patients with Graves' disease and ten of the patients with toxic multinodular goiter. The results of this study revealed that there were a statistically highly significant increase in plasma malan-dialdehyde (MDA), a significant decrease in plasma thiol and very highly significant decrease in total antioxidant activity in both patient groups when compared to healthy controls. After treatment, plasma MDA levels
Recommended Citation
El-Baz, Ayman; El-Kholy, Ahmed; Abd El-Latif, Mohamed; and Mokhtar, Naglaa
(2005)
"BIOCHEMICAL EVALUATION OF SOME INDICES OF OXIDATIVE STRESS IN PATIENTS WITH HYPERTHYRODISM BEFORE AND AFTER TREATMENT,"
Mansoura Medical Journal: Vol. 34
:
Iss.
1
, Article 6.
Available at:
https://doi.org/10.21608/mjmu.2005.127758
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