Article Type
Original Study
Abstract
Acetaminophen is one of the most common pharmaceuticals associated with both intentional and accidental poisoning. Acetaminophen-induced hepatotoxicity is the most frequent cause of fulminant liver failure, and can have a mortality rate 90%. The present work aimed at the investigation of the possible effect of trimetazi-dine in preventing acetaminophen -induced hepatotoxicity and comparing it with the traditionally used N- acetyl cysteine for the same purpose. The present study was carried out on 40 mice. Mice were divided into 2 main groups. Group I: consisted of 10 animals considered as control group and received saline. Group II: consisted of 30 animals which were subdivided into 3 equal subgroups (10 mice/ subgroup) as follows : subgroup (IIA): served as acetaminophen only treated group.in a dose of 500 mg/kg intra-gastrically. Subgroup (KB): acetami-nophen treated mice treated with N-acetyl cysteine in a dose of 200mg/kg intragastrically one hour before administration of acetaminophen. Subgroup (IIC): acetaminophen treated mice treated with trimetazidine in a dose of 20 mg/kg intragastrically one hour before administration of acetaminophen. Liver cell integrity was monitored by measurement of serum glu-tamate pyruvate transaminase (SGPT). Glutathione (GSH) in blood and malondialdehyde (MDA) in serum were assessed. Liver cell integrity was also confirmed by histopathologi-cal examination for assessing the distribution and extent of cell death. Mice treated with acetaminophen only
Recommended Citation
Hassanin, Amal; Serag, Sober; and Tantawy, Dina
(2005)
"ROLE OFTR1METAZIDINE IN PREVENTING ACETAMINOPHEN-INDUCED HEPATIC INJURY IN MICE,"
Mansoura Medical Journal: Vol. 34
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2005.128102
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This work is licensed under a Creative Commons Attribution 4.0 International License.
