Article Type
Original Study
Abstract
30 adult albino rats were used in this study. They were divided into 3 groups (10 rats each): Adult male, female and pregnant rats. Each group was subdivided into control and treated ones. The treated rats were given 10% Mirazid emulsion (new natural schistosomicidal drug obtained from Myrrh), provided from Pharco Phar-macuticals, Alexandria, Egypt. It was given orally in a dose 200 mg/ Kg body weight, one hour before breakfast, for six successive days. The pregnant rats were given the same dose starting day 6 to day 11 of pregnancy and were observed for abortions, numbers of newly born fetuses which examined for any congenital abnormalities. No abortions were noted in the treated pregnant rats. The number of pups for each treated ones was higher than those of control mothers. Also, the pups of treated mothers were similar in weight to the control and no congenital anomalies were seen. The rats were sacrificed at one and seven days after administration of the last dose with Mirazid. They were thoroughly dissected for the liver, pancreas, kidney and testis or ovaries, which then fixed in 10% formaldehyde. Sections were prepared and stained by haematoxylin and eosin. Haematoxylin and eosin stained sections of the liver, one day after the administration of the last dose of the drug, showed little infiltration with lymphocytes, slight dilatation of liver sinusoids with scanty vacuolation of its cells. However.
Recommended Citation
Shaaban, Ibrahim
(2005)
"A STUDY ON THE EFFECT OF MIRAZID ON SOME OF THE INTERNAL ORGANS AND ITS POSSIBLE PRENATAL EFFECT IN ALBINO RAT,"
Mansoura Medical Journal: Vol. 34
:
Iss.
2
, Article 5.
Available at:
https://doi.org/10.21608/mjmu.2005.128135
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