Article Type

Original Study


30 adult albino rats were used in this study. They were divided into 3 groups (10 rats each): Adult male, female and pregnant rats. Each group was subdivided into control and treat­ed ones. The treated rats were given 10% Mirazid emulsion (new natural schistosomicidal drug obtained from Myrrh), provided from Pharco Phar-macuticals, Alexandria, Egypt. It was given orally in a dose 200 mg/ Kg body weight, one hour before break­fast, for six successive days. The pregnant rats were given the same dose starting day 6 to day 11 of preg­nancy and were observed for abor­tions, numbers of newly born fetuses which examined for any congenital abnormalities. No abortions were not­ed in the treated pregnant rats. The number of pups for each treated ones was higher than those of control mothers. Also, the pups of treated mothers were similar in weight to the control and no congenital anomalies were seen. The rats were sacrificed at one and seven days after administration of the last dose with Mirazid. They were thoroughly dissected for the liver, pancreas, kidney and testis or ovaries, which then fixed in 10% formaldehyde. Sections were pre­pared and stained by haematoxylin and eosin. Haematoxylin and eosin stained sections of the liver, one day after the administration of the last dose of the drug, showed little infil­tration with lymphocytes, slight dilata­tion of liver sinusoids with scanty vacuolation of its cells. However.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.