Article Type
Original Study
Abstract
This experimental study was carried to evaluate the possible therapeutic effects of amlodipine on collagen-induced arthritis in rats. Collagen arthritis were induced in a sprague dawley rats by intradermal injection of total volume of 0.1 ml of cold emulsion consisting of native type II collagen and complete freund's adjuvant with a second immunization was given after 21 days. Rats were divided into two main groups: group A, received 0.5 ml saline solution and served as normal control, group B, arthritic group, this group was subdivided into two equal subgroups each compromised 10 rats as follows, group I, arthritic control which treated with saline and group 2 amlodipine treated arthritic group (50 ug/kg). For all groups, drugs were given as a single daily intramuscular injection for 18 days next day after the second immunization. Paws were examined mac-roscopically for redness, swelling and deformities. The severity of arthritis was evaluated by histopathological scoring of the knee joints and biochemically by measuring serum levels of TNF-a, IL-lp, nitric oxide and serum maiondialdehyde. It was found that administration of amlodipine significantly suppressed the progression of arthritis and decreased the production of TNF-ct. IL- ip, nitric oxide as well as maiondialdehyde levels in the serum. In conclusion, these findings indicate that administration of amlodipine may have significant therapeutic effect on the rat model of rheumatoid arthritis which was probably due to antioxidant effect and inhibition of pro-inflammatory cytokines as well as nitric oxide production.
Recommended Citation
A, Shalaby and A, EIHawary
(2006)
"AMLODIPINE; A NEW THERAPEUTIC STRATEGY IN RHEUMATOID ARTHRITIS,"
Mansoura Medical Journal: Vol. 35
:
Iss.
1
, Article 10.
Available at:
https://doi.org/10.21608/mjmu.2006.128747
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This work is licensed under a Creative Commons Attribution 4.0 International License.
