Article Type
Original Study
Abstract
Renal ischemia is of great clinical interest because of its role in renal failure and renal graft rejection. The purpose of this study was to investigate the possible protective effect of leflunomide against ischemia/ reperlusion (I/R) injury in the rat. Methods: Three groups of Sprague-Dawley rats (10 rats each), the control group, I/R group and the leflunomide - treated I/R group. A renal I/R injury was induced by a left renal pedicle occlusion to induce ischemia for 45 min, followed by 60 mins of reper-fusion with contralateral nephrectomy In rats. The rats in Leflunomide treated l/R group were pretreated intra-gastrically with a leflunomide suspension (10 mg/kg) 60 min before the ischemia induction. Thio barbituric acid reactive substances (TEARS), nitric oxide (NO), tumor necrosis factor alpha (TNF-ct), catalase (CAT) su-peroxide dismutase (SOD) activities were determined in renal tissue, while, creatinine, blood urea nitrogen (BUN) were measured in blood. Results: Our results indicate that TBARS, NO, TNF-a, BUN and creatinine levels, were significantly higher in the I/R group than those in the control group. Leflunomide administration significantly decreased these parameters. SOD and CAT activities significantly decreased after I/R injury when compared to the control group. Leflunomide treatment significantly increased activities of these enzymes when compared to the I/R group.
Recommended Citation
Shalaby, Amany; Atwa, Amany; and Morsy, Heba
(2006)
"RENOPROTECTIVE EFFECT OF LEFLUNOM1DE AGANIST ISCHEMIA-REPERFUSION INJURY IN RATS,"
Mansoura Medical Journal: Vol. 35
:
Iss.
1
, Article 14.
Available at:
https://doi.org/10.21608/mjmu.2006.128756
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This work is licensed under a Creative Commons Attribution 4.0 International License.
