Article Type
Original Study
Abstract
Cyclooxygenase-2 (COX-2) enzyme is induced in the central nervous system after various insults. It has been localized to neurons and in cells associated with the cerebral vas-culature where the system is involved in the inflammatory component of the ischaemic cascade, COX-2 is part of the initial reaction that involves the arachidonic acid cascade, which produces molecules that involved in inflammatory response. The present study evaluated the pharmacological effects of a specific COX-2 inhibitor (rofecoxib), in a permanent focal cerebral ischaemia model in albino rats and its effects were compared to those of calcium channel blocker (ni-modipine). Experiments were carried out on sixty male albino rats. Focal cereberal ischemia was induced by middle cerebral artery occlusion. Rofecoxib and nimodipine were administered 30 minutes after the occlusion of middle cerebral artery [MCA] and then daily IP for successive 6 days during which neurobehav-ioral evaluation was done. On the 7th day of occlusion, the infarction size, was measure and the remote hippo-
Recommended Citation
El-Banna, Farida; Yassen, Abdel Rahman; Saad, Ahdy; Abdel Rahman, Karawan; and Boshra, Vivian
(2006)
"EVALUATION OF THE ANTI-ISCHAEMIC EFFECT OF SELECTIVE COX-2 INHIBITOR (ROFECOXIB) IN PERMANENT LEFT MIDDLE CEREBRAL ARTERY OCCLUSION (FOCAL CEREBRAL ISCHEMIA MODEL) IN RATS,"
Mansoura Medical Journal: Vol. 35
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2006.128760
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This work is licensed under a Creative Commons Attribution 4.0 International License.
