ROLE OF SPERMATIC VEIN INHIBIN B AND LDH ACTIVITY AS PREDICTORS OF TESTICULAR DYSFUNCTION IN VARICOCELE PATIENTS

Authors

Hosam Ghanem, Clinical Pathology Department department" Mansoura University
Abdel-Azeim EL-Ganish, General Surgery Department department" Mansoura University
Ahmed Moatamd, General Surgery Department department" Mansoura University
Kamal Abd-eleilah, General Surgery Department department" Mansoura University
Wagih. Ghnnam, General Surgery Department department" Mansoura University
Nashaat Noaman, General Surgery Department department" Mansoura University
Mahmoud Amin, General Surgery Department department" Mansoura University

Article Type

Original Study

Abstract

Inhibin B generated by Sertoli cells provides negative feedback on FSH secretion. In men, inhibin B seems to be physiologically important form of inhibin. Lactic dehydrogenase (LDH), an intracellular enzyme that indicates cellular damage. Varicocele has been associated with infertility and dis­turbed spermatogenesis . We aimed to investigate the rela­tionship between varicocele, LDH and inhibin B. This study was conducted on forty infertile men with varicocele and twenty age matched control men. LDH and inhibin B were measured in the blood samples of these 40 pa­tients with varicocele which were ob­tained synchronously from spermatic and peripheral veins during operation and in peripheral vein of control men. Varicocele patients were classified into two groups: group I twenty pa­tients with normal sperm concentra­tion (> 20 million /ml), and group II twenty patients with low sperm con­centration {< 20 million /ml). FSH and testosterone were meas­ured by chemiluminescence while in­hibin B was measured by enzyme immunoassay method. LDH enzyme

Recommended Citation

Ghanem, Hosam; EL-Ganish, Abdel-Azeim; Moatamd, Ahmed; Abd-eleilah, Kamal; Ghnnam, Wagih.; Noaman, Nashaat; and Amin, Mahmoud (2006) "ROLE OF SPERMATIC VEIN INHIBIN B AND LDH ACTIVITY AS PREDICTORS OF TESTICULAR DYSFUNCTION IN VARICOCELE PATIENTS," Mansoura Medical Journal: Vol. 35 : Iss. 2 , Article 3.
Available at: https://doi.org/10.21608/mjmu.2006.128761

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