EFFECTS OF RISEDRONATE SODIUM ON THE TIBIAE OF THE ALBINO RATS ON BETAMETHASONE THERAPY. A LIGHT AND ELECTRON MICROSCOPE STUDY.

Authors

Gamal Mohamed, Anatomy Department, Faculty Of Medicine, Mansoura Universty.

Article Type

Original Study

Abstract

Glucocorticoids (GCs) are widely utilized in medical practice to combat diseases having an inflammatory ele­ment. The aim of the present study is to throw light on the effects of risedro-nate sodium (Ris)on the architecture of the tibiae of the albino rats on beta-methasone (Bet) therapy. Thirty adult male albino rats (200-250 gm) were used in this study. They were ran­domized into three equal groups:control, Bet-treated and both Bet- and Ris-treated. At sacrifice, small pieces of the decalcified tibiae were processed to prepare paraffin sections stained with haematoxylin and eosin (H&E) and Masson's tri- chrome. Other ultra-thin sections stained with uranyl acetate and lead citrate for EM study were, also, pre­pared. The tibiae of the Bet-treated rats showed an apparently marked decrease in the amount of collage-nous fibres, separation and thinning of the pesiosteum, notches at the bone surfaces, resorption cavities filled with granulation tissue, irregular sizes and distribution of Haversian canals as well as non-homogenous dark and pale areas of the matrix. Ul­tra-structural ly, the osteoblasts got degenerated. They lost their process­es and became smooth. Their cyto­plasm lacked its organelles and gained many vacuoles

Recommended Citation

Mohamed, Gamal (2008) "EFFECTS OF RISEDRONATE SODIUM ON THE TIBIAE OF THE ALBINO RATS ON BETAMETHASONE THERAPY. A LIGHT AND ELECTRON MICROSCOPE STUDY.," Mansoura Medical Journal: Vol. 37 : Iss. 2 , Article 11.
Available at: https://doi.org/10.21608/mjmu.2008.129226

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