Article Type
Original Study
Abstract
Background and aim : Carcinoma of the breast is the most prevalent cancer among Egyptian women. P53 overexpression is the most common genetic alteration found in breast cancer. The growth and proliferation of tumor cells, as well as their metastat-ic dissemination, have been shown to be preceded and facilitated by the formation of new blood vessels (angio-genesis). This work aimed to determine p53 expression and angiogenesis measured by microves-sel density (MVD) in invasive breast carcinoma. Also, to study the relationship between p53 expression and the degree of angiogenesis. Patients and methods : The present study was performed on the paraffin blocks from the tumors of 40 modified radical mastectomy specimens (done for invasive breast carcinoma). Immunohistochemical staining for p53 and CD34 (marking endo-thelial cells for MVD assessment) was done. Results : In this study, p53 was positive in 60 % of invasive breast carcinomas. P53 positivity was highest in tumors of patients in the fifth decade, premenopausal, tumors of grade II, with a size of 2-5 cm, with positive axillary L.Ns and stage MB.
Recommended Citation
El-Salkh, Iman; Atwan, Nadia; Sirag, Soheir; Abu hashim, Maha; Zalata, Khaled; Onsy, Hany; and Awad, Ibrahim
(2008)
"P53 AND MICROVESSEL DENSITY (MVD) IN INVASIVE BREAST CARCINOMA: IMMU-NOHISTOCHEMICAL STUDY.,"
Mansoura Medical Journal: Vol. 37
:
Iss.
2
, Article 5.
Available at:
https://doi.org/10.21608/mjmu.2008.129211
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
