MONOSODIUM GLUTAMATE VERSUS DIET INDUCED OBESITY IN PREGNANT RATS AND THEIR OFFSPRING

Authors

Mohammed Afifi, Biochemistry department Faculty of Medicine. Zagazig University'
Amr Abbas, Department of Medical Physiology, Faculty of Medicine. Msnsoura University, Egypt'

Article Type

Original Study

Abstract

Background arc] aim. We aim to eeteririhe the role cf MSG compared with high caloric chow (HCC) in de­velopment of cbosilypregnant rats and thei- offspring. Materials and Methods. Ninety pregnant rals were divided into 3 groups control MSG and HCC fed. We 'Jetfirrnined body weight (BW), boly fat, fat to body weight ratio, ser­um g'ucc.se, insu'in, leptin, Lpid pro­file, ob and lept'n receptor-b gene ex­pressions in pregnant rats and ob and l&ptin recepto;-b gene expressions, serum ins'jlin, glucose, leptin, triacyl-glycerides, total lipids and body weight in offspring. Results- Daily food intake and BW deceased wh;!e body fat and fat body weight ratio increased in MSG relative to HCC ted rais. MSG or HCC increased Ob gene expression, ioptin, insulin, LDL, VLDL. choleste­rol, 'otal lipids (TL), glucose and de­creased ieptm receptor-b gene ex­pression. In orfsoring of MSG treated rats. BW, serum glucose, insulin, itp-lin, triacylgiyc'c-rlops. TL and Ob gene expression increased and leptin re­ceptor-b gene expression decreased whereas in offspring of HCC fed rats, serum insulin, iepun, Ob and Ieptm re-cepior-b gene expression increased but no significant increase in serum glucose, triacylglycerides, TL or BW.

Recommended Citation

Afifi, Mohammed and Abbas, Amr (2009) "MONOSODIUM GLUTAMATE VERSUS DIET INDUCED OBESITY IN PREGNANT RATS AND THEIR OFFSPRING," Mansoura Medical Journal: Vol. 38 : Iss. 1 , Article 2.
Available at: https://doi.org/10.21608/mjmu.2009.130324

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