Article Type

Original Study


Background arc] aim. We aim to eeteririhe the role cf MSG compared with high caloric chow (HCC) in de­velopment of cbosilypregnant rats and thei- offspring. Materials and Methods. Ninety pregnant rals were divided into 3 groups control MSG and HCC fed. We 'Jetfirrnined body weight (BW), boly fat, fat to body weight ratio, ser­um g'ucc.se, insu'in, leptin, Lpid pro­file, ob and lept'n receptor-b gene ex­pressions in pregnant rats and ob and l&ptin recepto;-b gene expressions, serum ins'jlin, glucose, leptin, triacyl-glycerides, total lipids and body weight in offspring. Results- Daily food intake and BW deceased wh;!e body fat and fat body weight ratio increased in MSG relative to HCC ted rais. MSG or HCC increased Ob gene expression, ioptin, insulin, LDL, VLDL. choleste­rol, 'otal lipids (TL), glucose and de­creased ieptm receptor-b gene ex­pression. In orfsoring of MSG treated rats. BW, serum glucose, insulin, itp-lin, triacylgiyc'c-rlops. TL and Ob gene expression increased and leptin re­ceptor-b gene expression decreased whereas in offspring of HCC fed rats, serum insulin, iepun, Ob and Ieptm re-cepior-b gene expression increased but no significant increase in serum glucose, triacylglycerides, TL or BW.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.