Article Type
Original Study
Abstract
Objective : The objective of the present study was to systemically evaluate the neurocognitive changes for two months after Whole brain radiotherapy (WBRT) and to evaluate time to neurocognitive failure using different reported mini-mental state examination (MMSE) cutoff score points (age/education and 23). Patients and methods: This study was conducted in Mansoura University Hospital (years 2007 & 2008) on 24 patients, 16 males and 8 females aged >18 years with more than 2 brain metastases. They received WBRT at a dose of 30 Gy in 10 equal daily fractions. Overall survival (OAS) measured from the date the patient first seen to the date of death or the date the patient was last known to be alive. The Folstein MMSE was done before, immediately and 2 months after WBRT to evaluate neurocognitive progression. Time to neurocognitive failure was evaluated using 2 oft-reported cutoff score points. Results: The median survival time was 4.5 months. The OAS was 45% at 6 month, 25% at 1 year, and 8.3% at 1.5 years. The OAS for patients 65 year-old, however the difference was statistically insignificant (p=0.21). 79.2% of patients developed deterioration, while 12.5% showed stable and 8.3% only developed improvement of cognitive function at two month. There was mild statistically significant deterioration of basal MMSE value immediately after WBRT (p=0.047)
Recommended Citation
Abu-Hegazy, Mohammad; El-Hadaad, Hend; and El-Beshbeshi, Wafaa
(2009)
"PROSPECTIVE EVALUATION OF NEUROCOGNITIVE EFFECTS IN PATIENTS WITH BRAIN METAST/ 'ES AFTER WHOLE BRAIN RADIOTHERAPY,"
Mansoura Medical Journal: Vol. 38
:
Iss.
1
, Article 4.
Available at:
https://doi.org/10.21608/mjmu.2009.130327
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This work is licensed under a Creative Commons Attribution 4.0 International License.
