Article Type
Original Study
Abstract
Oxidative stress induced by hyper-glycemia in diabetes mellitus is a major cause for development and progression of diabetic microvascular complications such as nephropathy. Thus, the protective action of trimeta-zidine "TMZ" against oxidative stress was investigated in a rat model of diabetic nephropathy. Diabetes was induced in male Sprague -Dawley rats using streptozotocin (65 mg/kg). Either TMZ (10 mg/kg) or captopril (50 mg/kg) was gavaged daily for 12 weeks. After the end of the experimental period, renal functions and renal oxidative stress markers were assessed. Either captopril or TMZ exhibited significant improvement of the renal function that was correlated with significant decrease in the renal oxidative stress markers. In conclusion, the antioxidant property of TMZ may offer a potential therapeutic source for the treatment of diabetic nephropathy.
Recommended Citation
Boshra, Vivian and Shalaby, Amany
(2009)
"EFFECTS OF TRIMETAZIDINE ON OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS,"
Mansoura Medical Journal: Vol. 38
:
Iss.
1
, Article 5.
Available at:
https://doi.org/10.21608/mjmu.2009.138441
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
