Article Type
Original Study
Abstract
Background and aim: We study the effects of melatonin and omepra-zole on rats with experimentally induced reflux esophagitis. Materials and methods: Sixty rats were divided into 12 sham operated rats and 48 rats with induced reflux esophagitis (RE), which were divided into either RE alone or pretreated by melatonin (MT), omeprazole or both, with or without inhibition of prosta-glandin (PG) generation by indometh-acin. Reflux esophagitis was induced in rats by ligating the pylorus and the junction between the forestomach and corpus. In all rats, gastric acid output, pH, nitric oxide (NO), melatonin, esophageal PGE2, malondialde-hyde (MDA) and reduced glutathione (GSH) were measured. The esophageal injury was assessed by macroscopic damage score, lesion length and microscopic regenerative epithelial changes and leucocytic infiltration scores. Results: Induction of RE increased gastric acid output, plasma NO, mucosal PGE2, MDA, decreased pH, plasma MT, GSH and caused esophageal mucosal injury. Indo-methacin administration to RE rats caused further increase in esophageal injury, acid output and decrease in pH and PGE2. Pretreatrnent with omeprazole significantly increased pH, decreased acid output, and esophageal injury in comparison to MT p < sup>retreatment. In addition, MT pre-treatment induced significant increase
Recommended Citation
Abbas, Amr; El Gendy, Ahmed; El Serougy, Hanaa; and El-Wahab, Ali
(2009)
"EFFECTS OF MELATONIN VERSUS OMEPRAZOLE ON REFLUX ESOPHAGITIS IN RATS,"
Mansoura Medical Journal: Vol. 38
:
Iss.
1
, Article 6.
Available at:
https://doi.org/10.21608/mjmu.2009.138479
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This work is licensed under a Creative Commons Attribution 4.0 International License.
