Article Type
Original Study
Abstract
Background: Vascular remodeling in idiopathic pulmonary fibrosis (IFF) is regulated by an imbalance between angiogenic and angiostatic factors. The identification of biomarkers for IFF could aid in the classification of disease subtypes, and provide a means to define therapeutic response. Endostatin is an anti-angiogenic peptide with known effects on endothelial cells. VEGF xxxb is a new family of VEGF isoform stimulates a unique pattern of VEGF-R2 receptor with anti-angiogenic activity and play important role in lung injury and repair. The present study examined weather the expression of endo-statin and VEGF xxxb differed among the histologic subgroups of IFF, usual interstitial pneumonia (UIP) which is steroid unresponsive type and nonspecific interstitial pneumonia (NSIP) which is steroid responsive type. Methods : The present study was conducted retrospectively using lung biopsies collected via vidoscopic tho-racscopy from 10 patients diagnosed as UIP and 10 patients diagnosed as NSIP pathologically. The control lung tissues from 6 patients were obtained from histologically normal areas of lung lobe removed for isolated benign tumors. The expression of en-dostatin and VEGF xxxb in lung tissues was assessed using immunohis-tochemistry studies.
Recommended Citation
Hasaneen, Nadia and El-Dosoky, Ibrahim
(2009)
"ENDOSTATIN AND VEGF xxx b ARE POTENTIAL DIAGNOSTIC MARKERS FOR IDIOPATHIC PULMONARY FIBROSIS,"
Mansoura Medical Journal: Vol. 38
:
Iss.
1
, Article 9.
Available at:
https://doi.org/10.21608/mjmu.2009.138490
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
