Article Type
Original Study
Abstract
Abstract: Iron is a necessary element for all living cells. Its deficiency with or without anemia is -the main cause of nutritional deficiency for human beings. In other words, there are many forms of diseases associated with excess iron storage. The clinically most important of which is hereditary hemochromatosis (HH). The present study was undertaken to investigate the correlation between biochemical, histopathological and im-munological changes in the parameters in liver injury models induced by carbonyl iron. 42 Sprague -Dawley rats were used in this study, 12 rats as control and 30 rats were treated with carbonyl iron at a dose of 3% of the chew diet for 24 hrs, 72 hrs, 1 week, 4weeks, 8 weeks and 12 weeks. The activity of serum transa-minases (ALT and AST), antioxidant enzymes (SOD, GSH and CAT), and blood platelets count and serum auto antibodies (ANA, ASMA and AMA or LKM) were determined. Liver samples of the control and treated animals at different times were stained with hematoxlene and eosin, Mas-son's trichrome and Peri's Prussian blue stains. Liver fibrosis was graded biochemically by liver fibrosis markers
Recommended Citation
Badria, Farid; Mancy, Seham; Salem, Tarek; Kenawy, Ayman; Elsaed, Wael; and Sobh, Mohamed
(2009)
"BIOCHEMICAL, IMMUNOLOGICAL AND HI STO PATHOLOGICAL CHANGES OF RAT LIVER INDUCED BY CARBONYL IRON,"
Mansoura Medical Journal: Vol. 38
:
Iss.
2
, Article 2.
Available at:
https://doi.org/10.21608/mjmu.2009.138494
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This work is licensed under a Creative Commons Attribution 4.0 International License.
