OXIDATIVE STATUS AND APOPTOSIS IN INFANTS AND CHILDREN WITH FEBRILE SEIZURE

Authors

Samir El Hassan, Department of pediatric infectious diseases and malnutrition, Faculty of medicine, Mansoura University, Egypt.
Mostafa El Ayouty, Department of pediatric infectious diseases and malnutrition, Faculty of medicine, Mansoura University, Egypt.
Mona Hafez, Department of pediatric infectious diseases and malnutrition, Faculty of medicine, Mansoura University, Egypt.
Maydaa Zaki, Department of pediatric infectious diseases and malnutrition, Faculty of medicine, Mansoura University, Egypt.
Mayada Husseini, Department of pediatric infectious diseases and malnutrition, Faculty of medicine, Mansoura University, Egypt.

Article Type

Original Study

Abstract

Objective : To assess the oxidativestatus and apoptosis in infantsandchildren with febrile seizure.Methods:This study includes all childrenhaving a febrile seizure eithersimpleor complex. They were 40 patientsand tweenty children as control. Blood sample was taken fromthepatients to measure serum totalanti-oxidantcapacity, MDA, solubleFas-L.Data was analyzed usingSPSS16. Results: We found thatchildren with FS had significantlyhigher oxidative stress levels (higherMDA 33.41±10.36 nmol/ml and lowerTAC median=0.55 Mm/L) (p≤0.001)& higher evidence of apoptosis atdiagnosis (Median sFas-L 150 ng/L)(p=0.003) than control group.Conclusion: the present work providesevidence for the increase in oxidative stress (higher MDA, lowerTAC) and apoptosis (higher s Fas-L)when compared with control. Infectionor fever per se may affect oxidativestress and apoptosis; which intheirturn may cause and complicateFS.An inverse relationship betweenTACand MDA leading to oxidativestressin FS. A correlation betweenoxidativestress and apoptosis.

Recommended Citation

El Hassan, Samir; El Ayouty, Mostafa; Hafez, Mona; Zaki, Maydaa; and Husseini, Mayada (2013) "OXIDATIVE STATUS AND APOPTOSIS IN INFANTS AND CHILDREN WITH FEBRILE SEIZURE," Mansoura Medical Journal: Vol. 42 : Iss. 2 , Article 3.
Available at: https://doi.org/10.21608/mjmu.2020.124912

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