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Article Type

Original Study

Abstract

Background: Parasites as hydatiddisease and amoebic liver abscesscan cause cystic lesions in the liverand their diagnosis depends on detectionof IgG antibodies in the serumin combination with imaging techniques.Aim of the work: To evaluate bothsensitivity and specificity of ELISAtest as a serological method for detectionof IgG antibodies in patientswithhydatid disease and amoebicliverabscess among patients withcysticlesions of the liver.Methodology: A case-controlstudy was conducted on 48 patientswith cystic lesions in the liver suspi cious to be hydatid cyst or amoebicliver abscess, during the period fromOctober 2012 to December 2013.Patients involved in the study wereadmitted to Mansoura UniversityHospital at the Tropical Medicine Departmentand were tested for antihydatidand anti-amoebic IgG antibodiesusing ELISA technique. Results: Thirty-one suspiciouscases of hydatid disease were examinedby histopathology, as a goldstandardtest, later; they were testedforIgG antibodies using ELISA. Histopathologydetected eleven casesashydatid disease in the liver, however,ELISA test recorded 10 positivecases and one case gave a falsenegativereaction, with sensitivity and specificity 90.9% and 95% respectively.Seventeen suspiciouscasesof hepatic abscess were testedusing IHA for anti-amoebic IgGantibodies,only 2 positive cases ofamoebicliver abscess were confirmed,the two cases were also positivewhen using the ELISA test withsensitivityand specificity 100% and93.3%respectively. Conclusion: ELISA is a highlysensitive and specific serologicaltechnique for diagnosis of hydatiddisease and amoebic liver abscessamong patients with cystic lesions ofthe liver.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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